Weight Loss & Obesity medication prices (2026)
FDA-approved weight-loss drugs include GLP-1 agonists (semaglutide as Wegovy, tirzepatide as Zepbound), phentermine, and orlistat. Brand GLP-1s are the most-asked-about prescriptions in the US in 2026 and routinely cost $1,000+/month without insurance.
Medically reviewed by Sara Marin, PharmD · Last verified 2026-05-18
All Weight loss medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Ozempic | Semaglutide | 1 mg/dose | $920.00 | $968.00 |
| Zepbound | Tirzepatide | 5 mg/dose | $1010.00 | $1059.00 |
| Mounjaro | Tirzepatide | 5 mg/dose | $1020.00 | $1069.00 |
| Wegovy | Semaglutide | 2.4 mg/dose | $1300.00 | $1349.00 |
FAQ
What is the cheapest medication for Weight loss?
Generic Semaglutide (Ozempic) averages $920.00 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Weight loss medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Weight loss drugs as good as brand?
Yes — the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.