Depression and Anxiety medication prices (2026)
SSRIs (sertraline, escitalopram, fluoxetine) and SNRIs (duloxetine, venlafaxine) are first-line antidepressants. Most have generic versions under $10/month cash. Brand Lexapro and Cymbalta can be 10× more expensive than their generics.
Medically reviewed by Sara Marin, PharmD · Last verified 2026-05-18
All Depression & anxiety medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Desyrel | Trazodone | 50 mg | $4.20 | $78.00 |
| Prozac | Fluoxetine | 20 mg | $4.40 | $148.00 |
| Zoloft | Sertraline | 50 mg | $5.20 | $178.00 |
| Vistaril | Hydroxyzine | 25 mg | $5.20 | $62.00 |
| Celexa | Citalopram | 20 mg | $5.80 | $168.00 |
| Remeron | Mirtazapine | 15 mg | $7.20 | $168.00 |
| Lexapro | Escitalopram | 10 mg | $7.40 | $212.00 |
| Xanax | Alprazolam | 0.5 mg | $7.40 | $92.00 |
| Valium | Diazepam | 5 mg | $7.40 | $112.00 |
| Paxil | Paroxetine | 20 mg | $7.80 | $182.00 |
| Ativan | Lorazepam | 1 mg | $8.20 | $98.00 |
| BuSpar | Buspirone | 10 mg | $8.40 | $112.00 |
| Lamictal | Lamotrigine | 100 mg | $9.40 | $312.00 |
| Klonopin | Clonazepam | 0.5 mg | $9.80 | $142.00 |
| Cymbalta | Duloxetine | 60 mg | $11.80 | $289.00 |
| Effexor XR | Venlafaxine | 75 mg | $12.20 | $312.00 |
| Seroquel | Quetiapine | 100 mg | $12.40 | $612.00 |
| Risperdal | Risperidone | 2 mg | $12.40 | $612.00 |
| Abilify | Aripiprazole | 10 mg | $18.00 | $892.00 |
| Wellbutrin XL | Bupropion | 300 mg | $18.40 | $398.00 |
| Zyprexa | Olanzapine | 10 mg | $18.40 | $898.00 |
FAQ
What is the cheapest medication for Depression & anxiety?
Generic Trazodone (Desyrel) averages $4.20 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Depression & anxiety medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Depression & anxiety drugs as good as brand?
Yes — the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.