Acid Reflux & GERD medication prices (2026)
Proton pump inhibitors (omeprazole, pantoprazole, esomeprazole) and H2 blockers (famotidine) treat GERD and frequent heartburn. Most are generic and available OTC or by prescription for under $10/month.
Medically reviewed by Sara Marin, PharmD · Last verified 2026-05-18
All Acid reflux medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Imodium | Loperamide | 2 mg | $3.80 | $10.99 |
| Dulcolax | Bisacodyl | 5 mg | $4.50 | $11.99 |
| Protonix | Pantoprazole | 40 mg | $5.40 | $148.00 |
| Pepcid AC | Famotidine | 20 mg | $5.90 | $16.99 |
| Zofran | Ondansetron | 4 mg | $7.20 | $312.00 |
| Preparation H | Phenylephrine/Hydrocortisone | - | $7.99 | $15.99 |
| MiraLAX | Polyethylene Glycol | 17 g | $9.20 | $24.99 |
| Prilosec OTC | Omeprazole | 20 mg | $9.50 | $24.99 |
| Nexium 24HR | Esomeprazole | 20 mg | $11.20 | $27.99 |
FAQ
What is the cheapest medication for Acid reflux?
Generic Loperamide (Imodium) averages $3.80 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Acid reflux medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Acid reflux drugs as good as brand?
Yes — the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.