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Mitochondrial / Metabolic
MOTS-c
Mitochondrial-derived peptide
A 16-amino-acid peptide encoded within mitochondrial DNA — a master regulator of metabolic homeostasis.

Compounded · 503A Pharmacy
Mechanism of action
Activates AMPK signaling, enhancing glucose uptake and fatty-acid oxidation while suppressing the methionine-folate cycle.
Studied uses
- ✓Insulin sensitivity & metabolic health
- ✓Exercise performance & VO₂ max
- ✓Healthy aging support
- ✓Body-composition optimization
Research highlights
- · Reverses age-dependent insulin resistance in mice
- · Increases physical capacity in aged murine models
- · Levels decline with age in human plasma
Side effects & cautions
- · Transient fatigue post-injection
- · Limited human trial data
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