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Sleep & Stress
DSIP
Delta Sleep-Inducing Peptide
A nine-amino-acid neuropeptide first isolated from rabbit cerebral venous blood during electrically induced sleep.
Compounded · 503A Pharmacy
Mechanism of action
Modulates GABAergic and corticotropin-releasing hormone pathways to lower stress reactivity and promote slow-wave sleep.
Studied uses
- ✓Sleep onset & deep-sleep promotion
- ✓Stress and cortisol regulation
- ✓Circadian rhythm reset (jet lag, shift work)
- ✓Chronic pain modulation
Research highlights
- · Improved sleep latency in chronic insomnia (small clinical trials)
- · Reduced opioid withdrawal symptoms in early studies
- · Decades of Soviet-era research
Side effects & cautions
- · Vivid dreams
- · Mild headache
- · Transient morning grogginess
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