How much does Prilosec OTC cost without insurance?

Prilosec OTC (Omeprazole) 20 mg costs around $9.50 cash for the generic and $24.99 for the brand. Live prices on this page are verified within the last 72 hours.

What pharmacy has the cheapest Prilosec OTC?

Cost Plus Drugs and Costco typically have the lowest cash price for generic Omeprazole. CVS and Walgreens are the most expensive. Exact rankings update live above.

How much does Prilosec OTC cost in Illinois without insurance?

Prilosec OTC (Omeprazole) 20 mg costs around $9.50 cash for the generic in Illinois. Most US chain pharmacies price prescriptions uniformly nationwide.

Where can I get the cheapest Prilosec OTC in Illinois?

Cost Plus Drugs (mail-order, ships to all 50 states), Costco, and Walmart usually have the lowest cash prices for Omeprazole in Illinois. CVS and Walgreens are typically the most expensive.

Does Illinois Medicaid cover Prilosec OTC?

Most state Medicaid programs cover generic Omeprazole with a low or zero copay. Brand Prilosec OTC usually requires prior authorization. Check your Illinois Medicaid formulary for the latest list.

Prilosec OTC

Name: Prilosec OTC 20 mg (Omeprazole)
Brand: Prilosec OTC
SKU: prilosec-otc

Omeprazole · 20 mg · tablet · qty 42

Also available in: 10mg · 20mg · 40mg

Frequent heartburn relief.

Medically reviewed by Sara Marin, PharmD · Last verified 2026-05-18

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Price summary

Form	Class	Brand avg	Generic avg	Savings
tablet 20 mg	OTC	$24.99	$9.50	62%

FAQ

Is generic Omeprazole the same as Prilosec OTC?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

On average $15.49 per fill (62% off the brand price). Savings vary by pharmacy — see live prices above.

Do I need insurance to get this price?

No. The prices shown on Tuesdays are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.